Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 24, Issue 30, Pages 7664-7670Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201800862
Keywords
chemotherapy; cytotoxicity; micelles; multimodal therapy; photodynamic therapy
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Funding
- FIR project of the University of Catania
- UTFPR
- CAPES [88881.119200/2016-01]
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In this contribution, we report a novel entirely photocontrolled nanoplatform comprising a binary mixture of pluronic copolymers capable of self-assembling into core-shell micelles and co-entrapping two photoactivatable components: a benzoporphyrin photosensitizer for photodynamic therapy (PDT) and coumarin-photocaged chemotherapeutic agent Chlorambucil (CAB). The resulting supramolecular micellar assembly is about 30 nm in diameter with a polydispersity index < 0.1, stable for more than 72 h, and exhibits excellent preservation of the photochemical properties of the two photoresponsive components, even though they are confined within the same host nanocarrier. Appropriate regulation of the relative concentrations of these components makes them capable of absorbing visible light in comparable amounts, leading to effective simultaneous photogeneration of singlet oxygen and photo-triggered release of CAB. This on demand release of cytotoxic combinations results in amplified anticancer activity against MCF-7 human breast adenocarcinoma cells.
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