Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 24, Issue 19, Pages 4810-4814Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201800641
Keywords
allylic alkylation; asymmetric catalysis; beta(2,2)-amino acids; beta-lactams; isoxazolidinones; palladium
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Funding
- CAPES foundation (Ministry of Education of Brazil)
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We report here an unprecedented and highly enantioselective palladium-catalyzed allylic alkylation applied to 4-substituted isoxazolidin-5-ones. Ultimately, the process provides a straightforward access to beta(2,2)-amino acids bearing an all-carbon quaternary stereogenic center in great yields and a high degree of enantioselectivity.
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