Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 24, Issue 42, Pages 10571-10583Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201800136
Keywords
continuous flow; diazo compounds; microreactors; organic synthesis; synthetic methods
Categories
Funding
- Excellence Initiative of the German federal and state governments
- Fonds der Chemischen Industrie
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Toxic, cancerogenic and explosivethese attributes are typically associated with diazo compounds. Nonetheless, diazo compounds are nowadays a highly demanded class of reagents for organic synthesis, yet the concerns with regards to safe and scalable transformations of these compounds are still exceptionally high. Lately, the research area of the continuous-flow synthesis of diazo compounds attracted significant interest and a whole variety of protocols for their on-demand preparation have been realized to date. This concept article focuses on the recent developments using continuous-flow technologies to access diazo compounds; thus minimizing risks and hazards when working with this particular class of compounds. In this article we discuss these concepts and highlight different pre-requisites to access and to perform downstream functionalization reaction.
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