Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 24, Issue 47, Pages 12269-12273Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201801772
Keywords
allylic alkynylation; C-H functionalization; copper; cross-dehydrogenative coupling; oxidation
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Funding
- German Academic Exchange Service, DAAD (Leadership for Syria Program)
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C-H bond functionalization is a well-developed concept that has been thoroughly studied and gives entry to rather complex molecules without the need for previous derivatization of the substrates. The use of copper complexes in allylic C-H bond functionalization under oxidative conditions as an alternative to the well-established palladium-based methodologies remains largely underdeveloped. Here, we show for the first time a selective cross-dehydrogenative coupling reaction between underivatized allylic substrates and terminal alkynes to produce 1,4-enynes in high yields in a single step, using an in situ synthesized copper catalyst and an oxidant.
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