Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 24, Issue 33, Pages 8447-8452Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201801520
Keywords
azamacrocycles; bioinorganic complexes; chelators; copper; peptides
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Funding
- ERC [StG-638712]
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Targeting copper ions to either remove or redistribute them is currently viewed as a possible therapeutic strategy in the context of Alzheimer's disease (AD). Thermodynamic parameters, as for instance the copper(II) affinity of the drug candidate or the copper(II) over zinc(II) selectivity, are considered in the design of the drug candidate. In contrast, kinetic factors have been overlooked despite their probable high importance. In the present article, we use a series of azamacrocyclic ligands to demonstrate that kinetic issues must be taken into account when designing copper-targeting drug candidates in the context of AD.
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