Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 24, Issue 28, Pages 7200-7209Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201800135
Keywords
adsorption; core-shell structures; drug delivery; mesoporous materials; nanoparticles
Categories
Funding
- University of Tubingen
- Deutsche Forschungsgemeinschaft
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A new class of hierarchically structured mesoporous silica core-shell nanoparticles (HSMSCSNs) with a periodic mesoporous organosilica (PMO) core and a mesoporous silica (MS) shell is reported. The applied one-pot, two-step strategy allows rational control over the core/shell chemical composition, topology, and pore/particle size, simply by adjusting the reaction conditions in the presence of cetyltrimethylammonium bromide (CTAB) as structure-directing agent under basic conditions. The spherical, ethylene-or methylene-bridged PMO cores feature hexagonal (p6mm) or cagelike cubic symmetry (Pm (3 n) depending on the organosilica precursor. The hexagonal MS shell was obtained by n-hexane-induced controlled hydrolysis of TEOS followed by directional co-assembly/condensation of silicate/CTAB composites at the PMO cores. The HSMSCSNs feature a hierarchical pore structure with pore diameters of about 2.7 and 5.6 nm in the core and shell domains, respectively. The core sizes and shell thicknesses are adjustable in the ranges of 90-275 and 15-50 nm, respectively, and the surface areas (max. 1300 m(2)g(-1)) and pore volumes (max. 1.83 cm(3)g(-1)) are among the highest reported for core-shell nanoparticles. The adsorption and controlled release of the fungicide propiconazole by the HSMSCSNs showed a three-stage release profile.
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