Journal
CHEMISTRY OF HETEROCYCLIC COMPOUNDS
Volume 54, Issue 3, Pages 292-301Publisher
SPRINGER
DOI: 10.1007/s10593-018-2263-5
Keywords
bioactive indole scaffolds; functionalized indole; heterocycles; indole; C-H activation; metal catalysis
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This review summarizes the metal-catalyzed approaches for the synthesis of privileged 2- and 3-functionalized indoles via the Fischer indole synthesis, cycloaddition reaction, C-H activation reaction, and coupling reactions. Polycyclic derivatives of indole are also listed including triptamine-based pharmaceutical 5-HT1D agonist L 775,606. Some important mechanism studies are described in details in this review. The review covers literature for the last 20 years.
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