Journal
CHEMISTRY LETTERS
Volume 47, Issue 3, Pages 350-353Publisher
CHEMICAL SOC JAPAN
DOI: 10.1246/cl.171139
Keywords
Nanopore and micropore; Ionic current sensing; Microfluidic bridge circuit
Categories
Funding
- PREST [JPMJPR151B, JPMJPR16F4]
- JST
- JSPS [17H04803, 16H02091]
- ImPACT Program of the Council for Science, Technology and Innovation (Cabinet Office, Government of Japan)
- [15J03490]
- Grants-in-Aid for Scientific Research [17H04803, 26706005, 16H02091] Funding Source: KAKEN
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Bridge circuit based ionic current sensing in a microfluidic channel has attracted attention as a highly sensitive analytical method for bio-related molecules and particles. However, channel geometry which greatly influences the detected ionic current has not been investigated. Here, we investigate experimentally and theoretically the effect of differences in the microfluidic channel geometry on shapes and amplitude of signals in ionic current sensing. Our results clarify the geometrical effect of the channel in the bridge circuit based ionic current sensing method.
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