4.3 Article

Synthesis of Diverse Phenothiazines by Direct Thioamination of Arynes with S-(o-Bromoaryl)-S-methylsulfilimines and Subsequent Intramolecular Buchwald-Hartwig Amination

Journal

CHEMISTRY LETTERS
Volume 47, Issue 7, Pages 825-828

Publisher

CHEMICAL SOC JAPAN
DOI: 10.1246/cl.180304

Keywords

Aryne chemistry; Thioamination; Phenothiazine

Funding

  1. Platform Project for Supporting Drug Discovery and Life Science Research (BINDS) from AMED [JP18am0101098]
  2. JSPS KAKENHI [15H03118, 18H02104, 16H01133, 18H04386, 26350971, 17J08217]
  3. Suntory Foundation for Life Sciences
  4. Naito Foundation

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A facile method for the synthesis of diverse phenothiazines has been achieved by direct thioamination of aryne intermediates with S-(o-bromoaryl)-S-methylsulfilimines and subsequent intramolecular Buchwald-Hartwig amination. Since various sulfilimines could be prepared easily by odorless copper-catalyzed ipso-thiolation of readily available o-bromoarylboronic acids followed by imination and hydrolysis, this approach enables the synthesis of a wide variety of multisubstituted phenothiazines.

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