Journal
CHEMISTRY LETTERS
Volume 47, Issue 7, Pages 825-828Publisher
CHEMICAL SOC JAPAN
DOI: 10.1246/cl.180304
Keywords
Aryne chemistry; Thioamination; Phenothiazine
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Funding
- Platform Project for Supporting Drug Discovery and Life Science Research (BINDS) from AMED [JP18am0101098]
- JSPS KAKENHI [15H03118, 18H02104, 16H01133, 18H04386, 26350971, 17J08217]
- Suntory Foundation for Life Sciences
- Naito Foundation
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A facile method for the synthesis of diverse phenothiazines has been achieved by direct thioamination of aryne intermediates with S-(o-bromoaryl)-S-methylsulfilimines and subsequent intramolecular Buchwald-Hartwig amination. Since various sulfilimines could be prepared easily by odorless copper-catalyzed ipso-thiolation of readily available o-bromoarylboronic acids followed by imination and hydrolysis, this approach enables the synthesis of a wide variety of multisubstituted phenothiazines.
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