Journal
CHEMISTRY LETTERS
Volume 47, Issue 6, Pages 770-772Publisher
CHEMICAL SOC JAPAN
DOI: 10.1246/cl.180181
Keywords
Liposome; Immunoglobulin G; Peptide
Categories
Funding
- JSPS KAKENHI [JP17K19204, JP16J04193]
- JSPS
- Grants-in-Aid for Scientific Research [16J04193] Funding Source: KAKEN
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Here we present a liposome non-covalently coated with immunoglobulin G (IgG) by using a peptide ligand to the constant region of IgG. IgG coated on the liposome still maintained binding ability to a complementary antigen protein but it was not recognized by Fc gamma receptors (Fc gamma Rs) of monocytes. The stealth feature of the IgG-coated liposome may be useful to avoid clearance by macrophages in vivo to extend the blood half-life of the liposome.
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