Journal
CHEMISTRY & BIODIVERSITY
Volume 15, Issue 3, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbdv.201700537
Keywords
Ventilago denticulata; quinone; radical scavenging activity; cytotoxic activity; antibacterial activity
Funding
- Center of Excellence on Environmental Health and Toxicology, Science & Technology Postgraduate Education and Research Development Office (PERDO), Ministry of Education
- Mahidol University
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New naphthalene derivatives (1 and 2) and a new isomer (3) of ventilagolin, together with known anthraquinones, chrysophanol (4), physcion or emodin 3-methyl ether (5), and emodin (6), were isolated from vines of Ventilago denticulata. The isolated compounds exhibited cytotoxic activity with IC50 values of 1.15 - 40.54 g/ml. Compounds 1 - 3 selectively exhibited weak antibacterial activity (MIC values of 200.0 - 400.0 g/ml), while emodin (6) displayed moderate antibacterial activity with MIC value of 25.0 g/ml. The isolated compounds showed nitric oxide and DPPH radical scavenging activities. Compounds 1 - 3 and 6 exhibited weak xanthine oxidase inhibitory activity, while emodin (6) acted as an aromatase inhibitor with the IC50 value of 10.1 m. Compounds 1 and 2 exhibited phosphodiesterase 5 inhibitory activity with IC50 values of 8.28 m and 6.48 m, respectively.
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