Journal
CHEMISTRY & BIODIVERSITY
Volume 15, Issue 2, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbdv.201700454
Keywords
Actinidiaceae; Actinidia chinensis; triterpenoid; cytotoxic activities
Funding
- Scientific Research Project of Colleges and Universities of Department of Education of Guangxi [KY2015YB178]
- Research Foundation of State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Guangxi Normal University [CMEMR2016-B16]
- Doctoral Foundation of Guangxi University of Science and Technology [14Z10]
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Phytochmical investigation of roots of Actinidia chinensisPlanch. led to the isolation triterpenoids 1 - 16, including a new compound 2,3,23,24-tetrahydroxyursa-12,20(30)-dien-28-oic acid (1). Their structures were identified on the basis of spectroscopic analysis, including 1D- and 2D-NMR, HR-ESI mass spectrometry, and by comparison with the literatures. The cytotoxicities of triterpenoids 1 - 16 against a panel of cultured human cancer cell lines (HepG2, A549, MCF-7, SK-OV-3, and HeLa) were evaluated. The new compound 1 exhibited moderate antitumor activities with IC50 values of 19.62 +/- 0.81, 18.86 +/- 1.56, 45.94 +/- 3.62, 62.41 +/- 2.29, and 28.74 +/- 1.07 m, respectively. The experiment data might be available to explain the use of roots of A. chinensis to treat various cancers in traditional Chinese medicine.
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