Journal
CHEMICAL SOCIETY REVIEWS
Volume 47, Issue 10, Pages 3574-3620Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7cs00877e
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Funding
- Swedish Research Council [VR 4-478/2016]
- Swedish Foundation for Strategic Research [SSF 4-3713/2016]
- Rosetrees Trust
- GlaxoSmithKline through the Imperial College London Engineered Medicines Laboratory Project
- ERC Seventh Framework Programme Consolidator grant Naturale CG [616417]
- Engineering and Physical Science Research Council (EPSRC) grant Bio-functionalised nanomaterials for ultrasensitive biosensing [EP/K020641/1]
- i-sense EPSRC IRC in Early Warning Sensing Systems for Infectious Diseases [EP/K031953/1]
- Wellcome Trust Senior Investigator Award [098411/Z/12/Z]
- EPSRC [EP/K031953/1, EP/K020641/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/K020641/1, EP/K031953/1] Funding Source: researchfish
- Rosetrees Trust [M676] Funding Source: researchfish
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Peptide- and protein-nanoparticle conjugates have emerged as powerful tools for biomedical applications, enabling the treatment, diagnosis, and prevention of disease. In this review, we focus on the key roles played by peptides and proteins in improving, controlling, and defining the performance of nanotechnologies. Within this framework, we provide a comprehensive overview of the key sequences and structures utilised to provide biological and physical stability to nano-constructs, direct particles to their target and influence their cellular and tissue distribution, induce and control biological responses, and form polypeptide self-assembled nanoparticles. In doing so, we highlight the great advances made by the field, as well as the challenges still faced in achieving the clinical translation of peptide- and protein-functionalised nano-drug delivery vehicles, imaging species, and active therapeutics.
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