Journal
CHEMICAL SOCIETY REVIEWS
Volume 47, Issue 11, Pages 4198-4232Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7cs00399d
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Funding
- Chinese Academy of Sciences [1600000012B2Q]
- American Diabetes Association [1-12-BS-243]
- PSC-CUNY Research Award [67155-00 45, 60281-00 48]
- National Natural Science Foundation (NSFC) [21271163, U1232211]
- CAS/SAFEA international partnership program for creative research teams
- CAS Hefei Science Center [2016HSC-IU011]
- Anhui Province Key Laboratory of Medical Physics and Technology [LMPT201701]
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Nanosized crosslinked polymer networks, named as nanogels, are playing an increasingly important role in a diverse range of applications by virtue of their porous structures, large surface area, good biocompatibility and responsiveness to internal and/or external chemico-physical stimuli. Recently, a variety of carbon nanomaterials, such as carbon quantum dots, graphene/graphene oxide nanosheets, fullerenes, carbon nanotubes, and nanodiamonds, have been embedded into responsive polymer nanogels, in order to integrate the unique electro-optical properties of carbon nanomaterials with the merits of nanogels into a single hybrid nanogel system for improvement of their applications in nanomedicine. A vast number of studies have been pursued to explore the applications of carbon-based hybrid nanogels in biomedical areas for biosensing, bioimaging, and smart drug carriers with combinatorial therapies and/or theranostic ability. New synthetic methods and structures have been developed to prepare carbon-based hybrid nanogels with versatile properties and functions. In this review, we summarize the latest developments and applications and address the future perspectives of these carbon-based hybrid nanogels in the biomedical field.
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