Journal
CHEMICAL REVIEWS
Volume 118, Issue 14, Pages 6893-6923Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.chemrev.7b00775
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Funding
- National Institutes of Health [R01CA172667]
- American Cancer Society Research Scholar Award [RSG14-242-01-TBE]
- National Science Foundation Graduate Research Fellowship [2015182321]
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Dysregulation of cancer cell metabolism contributes to abnormal cell growth, the biological end point of cancer. We review here numerous affected oncogenes and metabolic pathways common in cancer and how they contribute to cancer pathogenesis and malignancy. This review also discusses various pharmacological manipulations that take advantage of these metabolic abnormalities and the current targeted therapies that have arisen from this research.
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