Journal
CHEMICAL RESEARCH IN TOXICOLOGY
Volume 31, Issue 3, Pages 165-167Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.chemrestox.8b00030
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Funding
- MIP-DILI project - IMI grant [115336]
- MRC CDSS grant [G0700654]
- MRC [MR/L006758/1, G0700654] Funding Source: UKRI
- Medical Research Council [G0700654, MR/L006758/1] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0512-10064] Funding Source: researchfish
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It is unclear whether priming of naive T cells to drugs is detectable in healthy human donors expressing different human leukocyte antigen (HLA) alleles. Thus, we examined T cell priming with drugs associated with HLA risk alleles and control compounds in 14 HLA-typed donors. Nitroso sulfamethoxazole and piperacillin activated T cells from all donors, whereas responses to carbamazepine and oxypurinol were only seen in donors expressing HLA-B*15:02 and HLA-B*58:01, respectively. Weak flucloxacillin-specific T cell responses were detected in donors expressing HLA-B*57:01 and HLA-B*58:01. These data show that the priming of T cells with certain drugs is skewed toward donors expressing specific HLA alleles.
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