Journal
CHEMICAL RECORD
Volume 19, Issue 1, Pages 77-84Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/tcr.201800048
Keywords
Acylation; design of experiments; flow synthesis; microwave chemistry; optimization
Categories
Funding
- Ministry of Education, Culture, Sports, Science and Technology (MEXT) [18H04397]
- Grants-in-Aid for Scientific Research [18H04397] Funding Source: KAKEN
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Generally, the flow method has the advantage of a precise control over the reaction parameters and a facile modification of the reaction conditions, while a continuous flow microwave reactor allows for the quick optimization of reaction conditions owing to the rapid uniform heating. In this study, we developed a 9+4+1 method to optimize reaction conditions based on comprehensive reaction analysis using a flow microwave reactor. The proposed method is expected to contribute to the synthesis of various fine and bulk chemicals by reducing cost and wastage, and by conserving time.
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