Journal
CHEMICAL ENGINEERING JOURNAL
Volume 350, Issue -, Pages 157-163Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.cej.2018.05.159
Keywords
MRSA; Equisetin; PVP nanofibers; Marine fungus; Skin and soft tissue infections
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Funding
- National Natural Science Foundation of China [81402876]
- Chongqing Municipal Bureau of Health Science and Technology of Traditional Chinese Medicine Project [ZY20132062]
- Chongqing Programs for Science and Technology Development [CSTC2015jcyjBX0018]
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Methicillin-resistant Staphylococcus aureus (MRSA) is emerging as a serious pathogenic bacterium in the clinical setting, and antibiotic resistance is spreading faster than the introduction of new agents to kill such bacteria. In our study, Fusarium sp. 152, a marine fungus obtained from the South China Sea, was fermented to screen new anti-MRSA compounds including equisetin (EQ) with a MIC value of 1 mu g/mL. Then, EQ was loaded into nanoparticle- based polyvinylpyrrolidone (PVP) electrospinning to facilitate its practical use. After electrospinning, the EQ nanofibers (EQ/NPs nanofiber) were 374.9 nm in diameter, and they showed a good flexibility and foldability. Additionally, the EQ/NPs nanofibers showed a better antibacterial effect both in vitro and in vivo than cefoxitin. Simultaneously, the infectious wounds treated with EQ/NPs nanofiber healed better and faster than those treated with EQ and cefoxitin. These findings strongly demonstrate that PVP-based electrospinning dressings are a candidate delivery carrier for the new anti-MRSA compound EQ for topical therapy.
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