4.7 Article

MRI and luminescence detection of Zn2+ with a lanthanide complex-zinc finger peptide conjugate

Journal

CHEMICAL COMMUNICATIONS
Volume 54, Issue 53, Pages 7350-7353

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c8cc04366c

Keywords

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Funding

  1. French National Research Agency [ANR-12-BS07-0012-01, ANR-13-JS07-0007]
  2. Labex ARCANE [ANR-11-LABX-0003-01]
  3. INBS France Life Imaging from the French Investissements d'Avenir program [ANR-11-INBS-0006]

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A bioinspired probe based on a zinc finger peptide functionalized by a lanthanide(iii)-DOTA monoamide complex turns out to be active for both luminescence and MRI detection of Zn2+, depending on the lanthanide cation. A mechanism for MRI-based detection is proposed.

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