Journal
CHEMICAL COMMUNICATIONS
Volume 54, Issue 59, Pages 8257-8260Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8cc04715d
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We have identified the bacterial signal recognition particle (SRP) as a novel antibacterial target. As a proof of principle, we used an antisense peptide nucleic acid to target a key SRP RNA. The PNA molecules showed efficient inhibition of SRP function and bacterial cell growth, thereby validating our hypothesis.
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