Journal
CHEMICAL COMMUNICATIONS
Volume 54, Issue 63, Pages 8725-8728Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8cc04913k
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Funding
- National Natural Science Foundation of China [21771089]
- Fundamental Research Funds for the Central Universities [JUSRP51725B, JUSRP51513]
- Project for Jiangsu Scientific and Technological Innovation Team
- MOE & SAFEA for the 111 Project [B13025]
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Four pairs of chiral supramolecular coordination cages were facilely synthesized, and they could efficiently inhibit amyloid-beta (A beta) aggregation with a high inhibition rate of 0.64-0.86. This research provides a new perspective on the design of chiral A beta inhibitors using supramolecular metal-organic cages.
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