Journal
CHEMICAL COMMUNICATIONS
Volume 54, Issue 25, Pages 3142-3145Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8cc00931g
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Funding
- National Natural Science Foundation of China [21775025, U1705281, U1505221, 21475026, 21635002]
- Natural Science Foundation of Fujian Province of China [2015H6011]
- Program for Changjiang Scholars and Innovative Research Team in University [IRT15R11]
- State Key Laboratory of Photocatalysis on Energy and Environment [2014B02]
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Gene therapy with small interfering RNA (siRNA) has been proved to be a promising technology to treat various diseases by hampering the production of target proteins. However, developing a delivery system that has high efficiency in transporting siRNA without obvious side effects remains a challenge. Herein, we designed a new survivin siRNA delivery system based on polyethyleneimine functionalized black phosphorus (BP) nanosheets which could suppress tumor growth by silencing survivin expression. Combined with the photothermal properties of the BP nanosheets, the presented delivery system shows excellent therapy efficiency for tumors. Therefore, the BP-based delivery system would be a promising tool for future clinical applications.
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