Journal
CHEMICAL COMMUNICATIONS
Volume 54, Issue 53, Pages 7302-7305Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8cc03311k
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We report a chemoselective and site-selective approach that distinguishes one Lys from its multiple copies, N-terminus, and other competitors. The phospha-Mannich protocol works with multiple proteins and installs probes without structural and functional perturbations. It delivers an antibody-drug conjugate with selective anti-proliferative activity towards HER2 expressing SKBR3 breast cancer cells.
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