Journal
CHEMICAL COMMUNICATIONS
Volume 54, Issue 51, Pages 6991-6994Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8cc03769h
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Funding
- National Natural Science Foundation of China [21325523, 21527811, 21735003, 21605098]
- Award for Team Leader Program of Taishan Scholars of Shandong Province, China
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We develop a label-free and high-throughput bioluminescence method for the sensitive detection of uracil DNA glycosylase (UDG) through enzyme-mediated tricyclic cascade signal amplification. This method exhibits high sensitivity with a detection limit as low as 0.00031 U mL(-1), and it can be further applied for the measurement of enzyme kinetic parameters and the screening of UDG inhibitors as well as cancer cell analysis.
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