Journal
CHEMICAL COMMUNICATIONS
Volume 54, Issue 51, Pages 7038-7041Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8cc03786h
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Funding
- National Natural Science Foundation of China [21576037, 21676047, 21421005]
- NSFC-Liaoning United Fund [U1608222]
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In this study, we reported a tamoxifen modified Ru(ii) polypyridyl complex (Ru-tmxf) as an estrogen receptor (ER) targeted photosensitizer. Ru-tmxf displays enhanced cellular uptake and PDT efficiency toward breast cancer cells with high ER expression due to the specific targeting of tamoxifen to ER and finally localizes in lysosomes. Moreover, Ru-tmxf can be activated by two-photon excitation, generating O-1(2) to damage lysosomes and result in cell death.
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