Journal
CHEMICAL COMMUNICATIONS
Volume 54, Issue 51, Pages 6995-6998Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7cc09927d
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Funding
- Ministry of Science and Technology (MOST), Taiwan [MOST 105-2628-B-197-001-MY3, MOST 106-2113-M-001-015]
- Taiwan International Graduate Program (TIGP), Academia Sinica
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This study established the comprehensive repeating unit structure of immunologically active glucuronoxylomannan (AAPS) from wood ear mushroom, Auricularia auricula-judae. We identified Toll-like receptor 4 (TLR4) as a critical receptor involved in AAPS-induced macrophage activation to secrete pro-inflammatory cytokines. Molecular modeling data and chemical modifications of AAPS revealed that both carboxylic and acetyl moieties of AAPS are equally essential in TLR4 binding to exert in vitro immunostimulatory activity.
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