Journal
CHEMICAL COMMUNICATIONS
Volume 54, Issue 50, Pages 6939-6942Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8cc02451k
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Funding
- JSPS KAKENHI Grant [16H00823, 16H05099, 18H04609]
- SENTAN, JST
- Mochida Memorial Foundation for Medical and Pharmaceutical Research
- JSPS Core-to-Core Program, A. Advanced Research Networks
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Si-Rhodamines are bright fluorophores with red to near-infrared (NIR) emission, and are widely used for fluorescence imaging of biological phenomena. Here, in order to extend the scope of Si-rhodamine fluorophores, we established a versatile synthesis of unsymmetrical Si-rhodamines. To illustrate its value, we used one of these new fluorophores to synthesize a far-red to NIR fluorescence probe for hypoxia, and showed that it can visualize hepatic ischemia in mice in vivo.
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