4.7 Article

High-yielding F-18 radiosynthesis of a novel oxytocin receptor tracer, a probe for nose-to-brain oxytocin uptake in vivo

Journal

CHEMICAL COMMUNICATIONS
Volume 54, Issue 58, Pages 8120-8123

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c8cc01400k

Keywords

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Funding

  1. EPSRC [EP/F500416/1, WT 088641/Z/09/Z]
  2. Medical Research Council [MR/K022733/1]
  3. Centre of Excellence in Medical Engineering by the Wellcome Trust
  4. Innovative Medicines Initiative Joint Undertaking from the European Union [115300]
  5. EFPIA
  6. Independent Researcher Award (King's College London)
  7. MRC [MR/K022733/1] Funding Source: UKRI

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A novel (AlF)-F-18 labelled peptide tracer for PET imaging of oxytocin receptor has been accessed through a high radiochemical yield approach. This tracer showed comparable affinity and higher selectivity and stability compared to oxytocin, and was used to demonstrate direct nose-to-brain uptake following intranasal administration, a common yet controversial delivery route for oxytocin-based therapeutics.

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