4.7 Article

Towards a sustainable synthesis of amides: chemoselective palladium-catalysed aminocarbonylation of aryl iodides in deep eutectic solvents

Journal

CHEMICAL COMMUNICATIONS
Volume 54, Issue 58, Pages 8100-8103

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c8cc03858a

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Funding

  1. Inter-university Consortium C.I.N.M.P.I.S.
  2. University of Bari
  3. University of Salento

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A palladium-catalysed aminocarbonylation of (hetero)aryl iodides has, for the first time, been accomplished in deep eutectic solvents as environmentally benign and recyclable media, under mild conditions. The reactions proceeded with a good substrate scope, and a variety of amides have been synthesized in yields up to 98%.

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