Journal
CHEMICAL COMMUNICATIONS
Volume 54, Issue 53, Pages 7338-7341Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8cc02638f
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- NWO Gravity Program Institute for Chemical Immunology (ICI)
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Reaction of cyclopropanated trans-cyclooctene (cpTCO) with in situ generated ortho-quinone is an efficient tool for bioorthogonal protein conjugation. The (4+2)-cycloaddition of cpTCO with ortho-quinone is significantly faster than its cyclooctyne counterpart (BCN). Orthogonal, tandem cpTCO-quinone and BCN-azide cycloadditions afforded a homogeneous, dual labelled antibody-drug conjugate.
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