4.7 Article

An intramolecular antiparallel G-quadruplex formed by human telomere RNA

Journal

CHEMICAL COMMUNICATIONS
Volume 54, Issue 32, Pages 3944-3946

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c8cc01427b

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Funding

  1. Grants-in-Aid for Scientific Research [17H03091, 16KT0048] Funding Source: KAKEN

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Until now, RNA G-quadruplexes were believed to only adopt a parallel G-quadruplex structure. In this study, we describe the first observation of an antiparallel RNA G-quadruplex formed by human telomere RNA. This newly described topology is of great interest as it shows that RNA G-quadruplexes can also be polymorphic and adopt structures that are different from the parallel configuration.

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