Journal
CHEMICAL COMMUNICATIONS
Volume 54, Issue 21, Pages 2615-2618Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7cc09571f
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Funding
- Nanjing Tech University [39837118, 39837101, 39837146]
- SICAM Fellowship from Jiangsu National Synergetic Innovation Center for Advanced Materials
- Nanyang Technological University
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An efficient copper-catalyzed three-component cyclization for the construction of highly functionalized pyrimidine derivatives from readily available amidines, styrenes and fluoroalkyl halides is developed. This protocol distinguishes itself by the formation of three new C-C/C-N bonds and a new six-membered ring through a radical addition/oxidation/cyclization sequence in a one-pot manner.
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