Journal
CHEMICAL COMMUNICATIONS
Volume 54, Issue 9, Pages 1057-1060Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7cc08222c
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Funding
- JSPS KAKENHI [17K01399, 26750162]
- Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan
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Stellated fibrous mesoporous silica nanospheres significantly improve the cellular uptake of cancer antigen and the maturation of bone marrow derived dendritic cells in vitro. Moreover, the combination of poly(I:C) with stellated fibrous MS nanospheres markedly decreases the necessary dose of poly(I:C) for anti-tumor immunity, and thus opens new opportunities for the future clinical application of poly(I:C) in cancer immunotherapy.
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