4.7 Article

Upconversion nanocrystal armoured' silica fibres with superior photoluminescence for miRNA detection

Journal

CHEMICAL COMMUNICATIONS
Volume 54, Issue 49, Pages 6324-6327

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c8cc03480j

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Funding

  1. National Nature Science Foundation of China [51672247]
  2. '111' Program - Education Ministry of China
  3. State Administration of Foreign Experts Affairs [B16043]
  4. Major State Research Program of China [2016YFC1101900]

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We have fabricated a flexible membrane, consisting of SiO2 nanofibres armoured with upconversion nanoparticles, exhibiting intense photoluminescence. These assemblies were subsequently grafted with molecular beacons to produce a biosensor suitable for the detection of specific microRNA and with applications in early cancer detection and point-of-care diagnosis.

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