Journal
CHEMICAL COMMUNICATIONS
Volume 54, Issue 49, Pages 6268-6271Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8cc02795a
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Funding
- National Science Foundation of China [21525105, 21471164, 21501201, 21778079]
- 973 Program [2015CB856301, 2015CB856302]
- Fundamental Research Funds for the Central Universities
- Pearl River S&T Nova Program of Guangzhou [201806010136]
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A hetero-binuclear Ir(iii)-Pt(ii) complex was developed as an antitumor agent. In vitro cytotoxicity results indicated that this complex was effective against cisplatin-resistant tumor cells. Mechanism experiments showed that it can overcome cisplatin resistance by increasing cellular uptake, targeting mitochondria, and inducing cell necrosis.
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