Journal
CHEMICAL COMMUNICATIONS
Volume 54, Issue 10, Pages 1237-1240Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7cc09130c
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Funding
- DARPA Folded Non-Natural Polymers with Biological Function Fold F(x) Program [N66001-16-2-4061]
- National Science Foundation [1607111]
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Expanding the chemical diversity of threose nucleic acid (TNA) beyond the natural bases would enable the development of TNA polymers with enhanced physicochemical properties. Here, we describe a versatile approach for increasing the chemical diversity of TNA using 5-alkynyl-modified alpha-L-threofuranosyl uridine triphosphates that are substrates for a TNA polymerase.
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