Journal
CHEMICAL COMMUNICATIONS
Volume 54, Issue 1, Pages 50-53Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7cc07079a
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Funding
- NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES [R01ES001670] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [T32GM080189] Funding Source: NIH RePORTER
- NIEHS NIH HHS [R01 ES001670] Funding Source: Medline
- NIGMS NIH HHS [T32 GM080189] Funding Source: Medline
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Polyketide synthases (PKSs) have several known editing mechanisms to ensure that non-productive intermediates are removed from the acyl carrier protein (ACP). We demonstrate that CitA, a putative hydrolase in the citrinin biosynthetic gene cluster, removes ACP-bound acyl intermediates. We propose that it serves an editing role in trans.
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