4.7 Article

A hydrogen fuel cell for rapid, enzyme-catalysed organic synthesis with continuous monitoring

Journal

CHEMICAL COMMUNICATIONS
Volume 54, Issue 8, Pages 972-975

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c7cc08859k

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Funding

  1. Biological and Biotechnological Research Council [BB/M005720/1, BB/P023797/1]
  2. SCG Chemicals (Thailand)
  3. China Scholarship Council
  4. Biotechnology and Biological Sciences Research Council [BB/P023797/1] Funding Source: researchfish
  5. BBSRC [BB/P023797/1] Funding Source: UKRI

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A one-pot fuel cell for specific, enzyme-catalysed organic synthesis, with continuous monitoring of rate and reaction progress, combines an electrode catalysing rapid, reversible and diffusion-controlled interconversion of NADP(+) and NADPH with a Pt electrode catalysing 2H(+)/H-2 interconversion. This Communication demonstrates its performance and characteristics using the reductive amination of 2-oxoglutarate as a test system.

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