Journal
CHEMICAL COMMUNICATIONS
Volume 54, Issue 26, Pages 3266-3269Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8cc00058a
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Funding
- Carl-Zeiss Foundation
- Friedrich Schiller University Jena
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Ynones are efficiently reduced with a mild hydride donor in the presence of a catalytic amount of nucleophilic phosphines. The reactions are selective 1,2-reductions that give propargyl alcohols in yields of up to 96%. It is proposed that success in these reactions depends on the activation of ynones by a Lewis base catalyst. A protic additive plays a key role in suppressing the undesired reaction pathways and accelerating the 1,2-reductions.
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