Journal
CHEMICAL COMMUNICATIONS
Volume 54, Issue 24, Pages 3014-3017Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8cc00398j
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Funding
- National Natural Science Foundation of China [31470963, 31470925, 31671021, 81630068, 31670881]
- Ministry of Science and Technology of China [2016YF1302305]
- National Major Scientific Instruments Development Project [91229203]
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How the rigidity of nanoparticles affects their penetration into tumors is unclear. Core-shell nanoparticles were prepared with amphipathic poly(ethylene glycol)-b-(poly epsilon-caprolactone-g-poly butyl acrylate) (PEG-(PCL-g-PBA)) so that the mechanical stiffness of their cores could be varied in order to test the relationship between their rigidity and penetration through tumors. The rigidity of the nanoparticles was adjusted by the changeable crystallinity of the core, which was altered by varying the ratio of epsilon-caprolactone and butyl acrylate.
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