Journal
CHEMICAL COMMUNICATIONS
Volume 54, Issue 22, Pages 2800-2803Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8cc00888d
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Funding
- Belarusian Foundation for Fundamental Research [X17PM-039]
- Russian Science Foundation [16-16-04057]
- Russian Science Foundation [16-16-04057] Funding Source: Russian Science Foundation
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Alkenes bearing a stereocenter in the allylic position were found to undergo Kulinkovich hydroxycyclopropanation with good diastereoselectivity. For the isomerization of the resulting cyclopropanols to diastereomerically enriched -methyl ketones, a new mild regioselective method has been developed. A sequence of stereoselective cyclopropanation and cyclopropanol ring opening was successfully employed for the construction of the C20 stereocenter in steroids.
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