Journal
CHEMICAL COMMUNICATIONS
Volume 54, Issue 30, Pages 3767-3770Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8cc00445e
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Funding
- National Key Research and Development Program of China [2016YFA0602900]
- National Natural Science Foundation of China [21420102003]
- Fundamental Research Funds for the Central Universities [2015ZY001]
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A novel copper-catalyzed annulation of oxime acetates and xanthates for the synthesis of thiazol-2-yl ethers with remarkable regioselectivity has been developed. Various oxime acetates, whether derived from aryl ketones or alkyl ketones, or natural product cores are suitable for this conversion. Unique dihydrothiazoles were also obtained when both reaction sites were methine. Mechanistic studies indicated that imino copper(iii) intermediates were involved. In addition, this protocol proceeded under redox-neutral conditions and did not require additives or ligands.
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