Journal
CHEMICAL COMMUNICATIONS
Volume 54, Issue 20, Pages 2463-2466Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7cc09384e
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Funding
- Hong Kong Baptist University [FRG2/16-17/007]
- Health and Medical Research Fund [HMRF/14130522, HMRF/14150561]
- Research Grants Council [HKBU/12301115, HKBU/201913]
- National Natural Science Foundation of China [21575121, 21628502]
- Guangdong Province Natural Science Foundation [2015A030313816]
- Hong Kong Baptist University
- Interdisciplinary Research Matching Scheme [RC-IRMS/15-16/03]
- Innovation and Technology Fund [ITS/260/16FX]
- Collaborative Research Fund [C5026-16G]
- Matching Proof of Concept Fund [MPCF-001-2017/18]
- Science and Technology Development Fund, Macao SAR [098/2014/A2]
- University of Macau [MYRG2015-00137-ICMS-QRCM, MYRG2016-00151-ICMS-QRCM]
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The rhodium(III) complex 1 was identified as a potent Wee1 inhibitor in vitro and in cellulo. It decreased Wee1 activity and unscheduled mitotic entry, and induced cell damage and death in TP53-mutated triple-negative breast cancer cells. 1 represents a promising scaffold for further development of more potent metal-based Wee1 antagonists.
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