Journal
CHEMICAL COMMUNICATIONS
Volume 54, Issue 46, Pages 5883-5886Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8cc02658k
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Funding
- US National Institutes of Health [R01GM111452]
- National Science Foundation [ECCS-1508845]
- Welch Foundation [E-1721]
- Texas Center for Superconductivity at the University of Houston (TcSUH)
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Probing biomolecular motion beyond a single nucleotide is technically challenging but fundamentally significant. We have developed super-resolution force spectroscopy (SURFS) with 0.5 pN force resolution and revealed that the ribosome moves by half a nucleotide upon the formation of the pre-translocation complex, which is beyond the resolution of other techniques.
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