Journal
CHEMICAL COMMUNICATIONS
Volume 54, Issue 46, Pages 5855-5858Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8cc01863d
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Funding
- Army Research Office (ARO) [W911NF-15-2-0119]
- National Science Foundation [CHE-1726291]
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The heteroleptic borane catalyst (C6F5)(2)B(CH2CH2CH2) BPin is found to hydrosilylatively reduce amides under mild conditions. Simple tertiary amides can be reduced using Me2EtSiH, whereas tertiary benzamides required a more reactive secondary silane, Et2SiH2, for efficient reduction. The catalytic system described exhibits exceptional chemoselectivity in the reduction of oligoamides and tolerates functionalities which are prone to reduction under similar conditions.
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