Journal
CHEMICAL COMMUNICATIONS
Volume 54, Issue 34, Pages 4286-4289Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8cc00526e
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Funding
- Stockholm Brain Institute
- VINNOVA
- Swedish Research Council (VR)
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Operationally simple radiosynthesis and purification of [F-18]fluoro-benziodoxole was developed starting from a cyclotron produced [F-18]F- precursor, [F-18]TBAF, and tosyl-benziodoxole. The synthetic utility of [F-18]fluoro-benziodoxole was demonstrated by electrophilic fluorocyclization of o-styrilamides proceeding with high RCC (typically 50-90%) and high molar activity (up to 396 GBq mol(-1)).
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