Copper-mediated regioselective C-H etherification of naphthylamides with arylboronic acids using water as an oxygen source

The copper-mediated regioselective C-H activation and C-O bond formation of naphthylamides with arylboronic acids has been developed using water as an oxygen source. The kinetic isotope study suggests that C-H bond activation is the rate-determining step. The H2O18 labelling experiment reveals the incorporation of oxygen from water. The substrate scope, functional group diversity and post synthetic utilities are the important practical features.