Journal
CHEMICAL COMMUNICATIONS
Volume 54, Issue 21, Pages 2599-2602Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7cc09129j
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Funding
- NIH [P30 CA08748]
- National Institutes of Health [R00 CA1440138]
- Thompson grant
- Francois Wallace Monahan Fellowship from the JLM Benevolent Fund
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The inverse electron-demand Diels-Alder reaction between tetra-zine (Tz) and trans-cyclooctene (TCO) facilitates the efficient radio-synthesis of Ac-225-labelled radioimmunoconjugates in a two-step method, outperforming conventional approaches based on isothio-cyanate couplings.
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