Journal
VACCINES
Volume 3, Issue 2, Pages 239-262Publisher
MDPI
DOI: 10.3390/vaccines3020239
Keywords
influenza; universal vaccine; MVA
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Funding
- European Research Council (ERC) grant FLUPLAN [250136]
- EU [602604]
- FLUPIG [FP7-GA258084]
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Influenza viruses have a huge impact on public health. Current influenza vaccines need to be updated annually and protect poorly against antigenic drift variants or novel emerging subtypes. Vaccination against influenza can be improved in two important ways, either by inducing more broadly protective immune responses or by decreasing the time of vaccine production, which is relevant especially during a pandemic outbreak. In this review, we outline the current efforts to develop so-called universal influenza vaccines, describing antigens that may induce broadly protective immunity and novel vaccine production platforms that facilitate timely availability of vaccines.
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