Journal
CELLULAR & MOLECULAR BIOLOGY LETTERS
Volume 20, Issue 5, Pages 788-797Publisher
BIOMED CENTRAL LTD
DOI: 10.1515/cmble-2015-0048
Keywords
Death domain associated protein; Function; Mutation; Expression; Localization; Interaction; Modification; Regulation; Transcription; Apoptosis
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Funding
- key discipline in Hunan province for Preclinical Medicine
- Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study (Hunan Provincial Education Department) [2012-1, 2014-405]
- Hunan Provincial Key Laboratory for Special Pathogens Prevention and Control (Hunan Provincial Science and Technology Department document) [2014-5]
- National Natural Science Foundation of China [81402169]
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Death domain associated protein (Daxx), a multi-functional protein, plays an important role in transcriptional regulation, cell apoptosis, carcinogenesis, anti-virus infection and so on. However, its regulatory mechanisms for both cell survival and apoptosis remain largely obscure. Our review of recent studies shows that Daxx has many interesting functional dualities and can provide a reference for further research on Daxx.
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